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Commitments and Contingencies (Details) (USD $)
12 Months Ended
Dec. 31, 2013
sqft
Item
Dec. 31, 2012
Dec. 31, 2011
Purchase Obligations
     
Information related to commitment and contingencies      
Total purchase obligations for services, development and supply agreements $ 800,000    
Operating Leases
     
Operating Leases      
Number of lease terms 2    
Additional lease period 5 years    
Area of buildings in South San Francisco, California (in square feet) 150,000    
Number of buildings 2    
Future minimum lease payments      
2014 4,859,000    
2015 5,770,000    
2016 5,943,000    
2017 6,121,000    
2018 6,305,000    
Thereafter 9,253,000    
Total 38,251,000    
Information related to commitment and contingencies      
Rent expense 5,972,000 5,720,000 6,702,000
Sublease income $ 0 $ (160,000) $ (637,000)