Collaborative Arrangements (Details) (USD $) In Thousands, unless otherwise specified	12 Months Ended
Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Information related to collaborative arrangements
Total net revenue	$ 4,758	$ 135,758	$ 24,512
GSK
Information related to collaborative arrangements
Total net revenue	4,532	5,613	9,658
Astellas
Information related to collaborative arrangements
Total net revenue	0	125,788	14,854
Other
Information related to collaborative arrangements
Total net revenue	$ 226	$ 4,357	$ 0

Amount of revenue recognized from goods sold, services rendered, insurance premiums, or other activities that constitute an earning process. Includes, but is not limited to, investment and interest income before deduction of interest expense when recognized as a component of revenue, and sales and trading gain (loss).

Reference 1: http://www.xbrl.org/2003/role/presentationRef

-Publisher FASB

-Name Accounting Standards Codification

-Topic 225

-SubTopic 10

-Section S99

-Paragraph 2

-Subparagraph (SX 210.5-03.1)

-URI http://asc.fasb.org/extlink&oid=26872669&loc=d3e20235-122688

Reference 2: http://www.xbrl.org/2003/role/presentationRef

-Publisher SEC

-Name Regulation S-X (SX)

-Number 210

-Section 03

-Paragraph 1

-Article 5

Name:	us-gaap_Revenues
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration