Commitments and Contingencies (Details) (USD $)	12 Months Ended
	Dec. 31, 2012 sqft	Dec. 31, 2011	Dec. 31, 2010
VIBATIV | Astellas
Information related to commitment and contingencies
Purchases of active pharmaceutical ingredient and other raw materials	$ 5,800,000
Purchase Obligations
Information related to commitment and contingencies
Total purchase obligations for services, development and supply agreements	2,500,000
Maximum | VIBATIV | Astellas
Information related to commitment and contingencies
Amount of purchase agreements for pharmaceutical ingredient and raw materials	7,700,000
Amount of finished goods inventories	4,200,000
Operating Leases
Operating Leases
Number of lease terms	2
Additional lease period	5 years
Area of buildings in South San Francisco, California (in square feet)	130,000
Number of buildings	2
Future minimum lease payments
2013	5,029,000
2014	4,859,000
2015	5,005,000
2016	5,155,000
2017	5,310,000
Thereafter	13,497,000
Total	38,855,000
Information related to commitment and contingencies
Rent expense	5,720,000	6,702,000	6,779,000
Sublease income, net	$ (160,000)	$ (637,000)	$ (622,000)