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Stock-Based Compensation (Details 2) (USD $)
1 Months Ended 12 Months Ended
Jun. 30, 2010
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Allocation of stock-based compensation expense        
Stock-based compensation expense   $ 23,783,000 $ 24,916,000 $ 19,009,000
Total stock-based compensation expense capitalized to inventory   400,000    
Information related to share-based compensation        
Total unrecognized compensation cost related to unvested stock-based compensation   43,994,000    
Performance-contingent
       
Information related to share-based compensation        
Timeframe for achievement of performance conditions     6 years  
Stock options
       
Allocation of stock-based compensation expense        
Stock-based compensation expense   3,417,000 4,528,000 7,003,000
Information related to share-based compensation        
Expense recorded in connection with stock option modification 900,000      
Total unrecognized compensation cost related to unvested stock-based compensation   6,442,000    
Weighted-average remaining service period of recognition of unrecognized compensation cost   2 years 7 months 6 days    
RSUs
       
Allocation of stock-based compensation expense        
Stock-based compensation expense   11,546,000 13,290,000 9,783,000
Information related to share-based compensation        
Total unrecognized compensation cost related to unvested stock-based compensation   14,027,000    
Weighted-average remaining service period of recognition of unrecognized compensation cost   2 years 1 month 6 days    
RSUs | Employee | Performance-contingent | Senior management
       
Allocation of stock-based compensation expense        
Stock-based compensation expense   300,000 1,300,000  
RSAs
       
Allocation of stock-based compensation expense        
Stock-based compensation expense   7,968,000 5,498,000 398,000
Information related to share-based compensation        
Total unrecognized compensation cost related to unvested stock-based compensation   23,525,000    
Weighted-average remaining service period of recognition of unrecognized compensation cost   3 years 6 months    
RSAs | Employee | Performance-contingent | Senior management
       
Allocation of stock-based compensation expense        
Stock-based compensation expense   400,000    
Information related to share-based compensation        
Timeframe for achievement of performance conditions     6 years  
Maximum potential expense associated with incentive compensation program     31,900,000  
RSAs | Non-employee | Performance-contingent | Non-executive officer
       
Information related to share-based compensation        
Maximum potential expense associated with incentive compensation program     475,000  
Non-employee options and RSUs
       
Allocation of stock-based compensation expense        
Stock-based compensation expense     307,000 1,186,000
ESPP
       
Allocation of stock-based compensation expense        
Stock-based compensation expense   852,000 1,293,000 639,000
Research and development
       
Allocation of stock-based compensation expense        
Stock-based compensation expense   13,667,000 13,422,000 10,322,000
Research and development | RSAs | Employee | Performance-contingent | Senior management
       
Information related to share-based compensation        
Maximum potential expense associated with incentive compensation program     6,300,000  
General and administrative
       
Allocation of stock-based compensation expense        
Stock-based compensation expense   10,116,000 11,494,000 8,687,000
General and administrative | RSAs | Employee | Performance-contingent | Senior management
       
Information related to share-based compensation        
Maximum potential expense associated with incentive compensation program     $ 25,600,000