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Consolidated Statements of Operations (USD $)
In Thousands, except Per Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Consolidated Statements of Operations      
Revenue (including amounts from a related party of $5,613 in 2012, $9,658 in 2011, and $9,826 in 2010) $ 135,758 $ 24,512 $ 24,223
Operating expenses:      
Research and development 117,898 103,568 75,070
General and administrative 30,859 30,681 27,476
Total operating expenses 148,757 134,249 102,546
Loss from operations (12,999) (109,737) (78,323)
Interest and other income 460 415 505
Interest expense (6,003) (6,022) (6,044)
Net loss $ (18,542) $ (115,344) $ (83,862)
Basic and diluted net loss per share (in dollars per share) $ (0.20) $ (1.41) $ (1.16)
Shares used in computing basic and diluted net loss per share (in shares) 90,909 82,051 72,070