Consolidated Statements of Operations (USD $) In Thousands, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2011	Dec. 31, 2010	Dec. 31, 2009
Revenue (including amounts from a related party of $9,658 in 2011, $9,826 in 2010, and $15,073 in 2009)	$ 24,512	$ 24,223	$ 24,374
Operating expenses:
Research and development	103,568	75,070	77,524
General and administrative	30,681	27,476	27,066
Restructuring charges			1,145
Total operating expenses	134,249	102,546	105,735
Loss from operations	(109,737)	(78,323)	(81,361)
Interest and other income	415	505	2,111
Interest expense	(6,022)	(6,044)	(6,052)
Net loss	$ (115,344)	$ (83,862)	$ (85,302)
Basic and diluted net loss per share (in dollars per share)	$ (1.41)	$ (1.16)	$ (1.35)
Shares used in computing basic net loss per share (in shares)	82,051	72,070	63,027
Shares used in computing diluted net loss per share (in shares)	82,051	72,070	63,027