Consolidated Balance Sheets (USD $) In Thousands, unless otherwise specified	Dec. 31, 2011	Dec. 31, 2010
Current assets:
Cash and cash equivalents	$ 44,778	$ 163,333
Marketable securities	196,137	146,301
Receivable from related party	223	194
Notes receivable, current	100	531
Prepaid and other current assets	3,525	5,995
Total current assets	244,763	316,354
Restricted cash	893	893
Property and equipment, net	10,372	10,215
Notes receivable, non-current	240	400
Other assets, non-current	2,514	3,340
Total assets	258,782	331,202
Current liabilities:
Accounts payable	5,813	2,128
Accrued personnel related expenses	9,643	8,617
Accrued clinical and development expenses	6,956	2,801
Accrued interest on convertible subordinated notes	2,372	2,372
Other accrued liabilities	1,946	2,008
Note payable and capital lease, current	69	206
Deferred revenue, current	18,697	21,922
Total current liabilities	45,496	40,054
Convertible subordinated notes	172,500	172,500
Deferred rent	5,821	3,574
Note payable and capital lease, non-current		69
Deferred revenue, non-current	122,017	137,425
Commitments and contingencies (Notes 3 and 9)
Stockholders' net capital deficiency:
Preferred stock, $0.01 par value, 230 shares authorized, no shares issued and outstanding
Additional paid-in capital	1,228,037	1,177,359
Accumulated other comprehensive income	16	33
Accumulated deficit	(1,315,960)	(1,200,616)
Total stockholders' net capital deficiency	(87,052)	(22,420)
Total liabilities and stockholders' net capital deficiency	258,782	331,202
Common stock
Stockholders' net capital deficiency:
Common stock	855	710
Class A common stock
Stockholders' net capital deficiency:
Common stock		$ 94