CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Cash flows from operating activities
Net income	$ 36,532	$ 34,865
Adjustments to reconcile net income to net cash provided by operating activities:
Deferred income taxes	3,244	(812)
Amortization of capitalized fees and depreciation of property and equipment	3,510	3,479
Amortization of acquired intangible assets	6,440	3,805
Inventory fair value step-up adjustment included in cost of products sold	6,843	6,842
Stock-based compensation	1,455	1,598
Amortization of debt discount and issuance costs	525	523
Changes in fair values of equity method investments, net	(35,342)	(15,817)
Changes in fair values of equity and long-term investments, net	13,335	2,164
Accrued interest income added to long-term investments	0	(1,482)
Other non-cash items	(1,513)	(2,062)
Changes in operating assets and liabilities:
Accounts receivable	315	(6,089)
Receivables from collaboration arrangement	7,750	(5,642)
Inventory	(3,543)	(598)
Prepaid expenses	5,079	5,440
Other assets	633	518
Accounts payable	(5,827)	2,994
Accrued personnel-related expenses and other accrued liabilities	441	(565)
Accrued interest payable	(2,589)	(3,526)
Income tax payable	49	49
Deferred revenue	(290)	0
Net cash provided by operating activities	37,047	25,684
Cash flows from investing activities
Purchases of trading securities	(43,136)	0
Purchases of equity and long-term investments	0	(35,689)
Purchases of equity investments managed by ISP Fund LP	(8,756)	(3,891)
Sales of equity investments managed by ISP Fund LP	5,342	1,289
Purchase and sales of other investments managed by ISP Fund LP, net	3,414	2,602
Purchases of property and equipment	0	(33)
Sale of property and equipment	98	0
Net cash used in investing activities	(43,038)	(35,722)
Cash flows from financing activities
Repurchase of common stock	(9,569)	(40,735)
Repurchase of shares to satisfy tax withholding	(84)	(23)
Proceeds from issuances of common stock, net	488	0
Payment for repurchase of convertible subordinated notes due 2023	0	(96,204)
Net cash used in financing activities	(9,165)	(136,962)
Net decrease in cash and cash equivalents	(15,156)	(147,000)
Cash and cash equivalents at beginning of period	193,513	291,049
Cash and cash equivalents at end of period	178,357	144,049
Supplemental Disclosure of Cash Flow Information:
Cash paid for interest	5,179	6,202
Supplemental Disclosure of Non-cash Investing and Financing Activities:
Accrued interest income converted to long-term investments	$ 799	$ 0