CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities
Net income	$ 179,722	$ 220,262	$ 368,837
Adjustments to reconcile net income to net cash provided by operating activities:
Deferred income taxes	4,400	25,006	76,432
Amortization of capitalized fees and depreciation of property and equipment	13,921	13,931	13,832
Amortization of acquired intangible assets	21,784	5,581	0
Inventory fair value step-up adjustment included in cost of products sold	27,164	10,023	0
Stock-based compensation	5,837	7,347	2,017
Amortization of debt discount and issuance costs	2,065	2,055	9,136
Changes in fair values of equity method investments, net	(77,392)	161,749	(84,392)
Changes in fair values of equity and long-term investments, net	(11,129)	(8,462)	(4,917)
Loss on extinguishment of debt	0	20,662	0
Net gain on sale of TRC	0	(266,696)	0
Other non-cash items	(517)	3,402	(259)
Changes in operating assets and liabilities:
Accounts receivable	(5,053)	(3,525)	0
Receivables from collaborative arrangements	(14,949)	13,319	(16,780)
Inventory	(12,004)	280	0
Prepaid expenses	7,929	(21,350)	203
Other assets	(2,965)	(3,341)	0
Accounts payable	3,778	92	(39)
Accrued personnel-related expenses and other accrued liabilities	(1,498)	11,913	(257)
Accrued interest payable	(937)	207	0
Deferred revenue	(817)	(755)	0
Income tax payable	1,725	10,026	0
Net cash provided by operating activities	141,064	201,726	363,813
Cash flows from investing activities
Purchases of equity method investments	0	(45,000)	(44,000)
Purchases of trading securities	(65,132)	0	(15,905)
Purchases of equity and long term investments	(1,218)	(13,725)	(6,373)
Purchases of equity investments managed by ISP Fund LP	(31,164)	(60,910)	(190,970)
Purchases of trading security managed by ISP Fund LP	0	(50,000)	0
Sales of equity investments managed by ISP Fund LP	72,500	24,281	21,440
Purchase and sales of other investments managed by ISP Fund LP, net	(41,336)	(23,371)	279,530
Purchases of property and equipment	(411)	(67)	0
Proceeds from sale of ownership interest in TRC, net	0	248,191	0
Cash acquired through the consolidation of Entasis	0	23,070	0
Cash paid for the acquisition of La Jolla, net of cash acquired	0	(159,103)	0
Net cash provided by (used in) investing activities	(66,761)	(56,634)	43,722
Cash flows from financing activities
Distributions to noncontrolling interest	0	(69,811)	(59,457)
Purchase of Entasis noncontrolling interest	0	(43,910)	0
Repurchase of common stock	(75,728)	(8,503)	(394,149)
Repurchase of shares to satisfy tax withholding	(77)	(82)	(60)
Proceeds from issuances of common stock, net	170	370	1,169
Payment for repurchase of convertible subordinated notes due 2023	(96,204)	(165,131)	0
Purchases of capped call options associated with convertible senior notes due 2028	0	(21,037)	0
Proceeds from issuance of convertible senior notes due 2028, net of issuance costs	0	252,536	0
Net cash used in financing activities	(171,839)	(55,568)	(452,497)
Net increase (decrease) in cash and cash equivalents	(97,536)	89,524	(44,962)
Cash and cash equivalents at beginning of period	291,049	201,525	246,487
Cash and cash equivalents at end of period	193,513	291,049	201,525
Supplemental disclosure of cash flow information:
Cash paid for interest	11,381	11,736	9,933
Cash paid for income taxes	0	53,855	0
Supplemental Disclosure of Non-cash Investing and Financing Activities:
Accrued interest income added to long-term investments	2,666	0	0
Adoption of ASU 2020-06	$ 0	$ (28,228)	$ 0