Debt - Schedule of Debt (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Dec. 31, 2022
Debt
Total debt	$ 453,500	$ 549,704
Less: Unamortized debt discount and issuance costs	(8,808)	(9,331)
Total debt, net	444,692	540,373
Less: Current portion of long-term debt, net	0	96,193
Total long-term debt, net	$ 444,692	444,180
HealthCare Royalty Partners
Debt
Maximum potential royalty payout	14.00%
Increase in maximum potential payout percent	4.00%
Maximum aggregate royalty payments	$ 225,000
Required payment for breach of agreement, payment one	125,000
Payment for royalty agreement	14,100
2023 Notes | Convertible subordinated notes
Debt
Total debt	0	96,204
2025 Notes | Convertible senior notes
Debt
Total debt	192,500	192,500
Less: Unamortized debt discount and issuance costs	(1,741)	(1,917)
2028 Notes | Convertible senior notes
Debt
Total debt	261,000	261,000
Less: Unamortized debt discount and issuance costs	(7,067)	(7,403)
Royalty Financing Agreement | Loans Payable [Member] | HealthCare Royalty Partners
Debt
Interest expense	1,200
Deferred Royalty Obligations	70,300	70,600
Royalty Payments	$ 1,400
Interest Rate of Deferred Royalty Obligation	7.19%
Royalty Financing Agreement | Loans Payable [Member] | HealthCare Royalty Partners | Other Long Term Liabilities
Debt
Royalty Obligation Payable	$ 67,100	67,900
Royalty Financing Agreement | Loans Payable [Member] | HealthCare Royalty Partners | Other Accrued Liabilities
Debt
Short term accrued interest	$ 3,200	$ 2,700