Equity and Long-term Investments and Fair Value Measurements - Schedule of Available-for-Sale Securities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2023		Dec. 31, 2022
Financial Instruments and Fair Value Measurements
Contingent value rights	$ 595		$ 595
ISP Fund LP
Liabilities
Lock-up period	36 months		36 months
Contributed to partnership for investing	$ 300,000		$ 300,000
ISP Fund LP | Convertible Debt
Assets
Total assets measured at estimated fair value	53,600
Money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	24,600		25,100
Equity investment | ISP Fund LP
Assets
Total assets measured at estimated fair value	264,900		295,400
Private Placement Positions and Convertible Notes | ISP Fund LP
Assets
Total assets measured at estimated fair value			54,600
Recurring basis
Assets
Total assets measured at estimated fair value	449,623		639,488
Recurring basis | Money market funds
Assets
Total assets measured at estimated fair value	75,426		263,469
Recurring basis | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	264,888	[1]	320,560	[2]
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1
Assets
Total assets measured at estimated fair value	380,156		560,546
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Money market funds
Assets
Total assets measured at estimated fair value	75,426		263,469
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	262,852	[1]	265,982	[2]
Recurring basis | Significant Other Observable Inputs, Level 2
Assets
Total assets measured at estimated fair value	13,093		8,059
Recurring basis | Significant Other Observable Inputs, Level 2 | Money market funds
Assets
Total assets measured at estimated fair value	0		0
Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	0	[1]	0	[2]
Recurring basis | Significant Unobservable Inputs, Level 3
Assets
Total assets measured at estimated fair value	56,374		70,883
Recurring basis | Significant Unobservable Inputs, Level 3 | Money market funds
Assets
Total assets measured at estimated fair value	0		0
Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	2,036	[1]	54,578	[2]
Nonrecurring basis
Financial Instruments and Fair Value Measurements
Contingent value rights	595		595
Liabilities
Total liabilities measured at estimated fair value	390,822		506,259
Nonrecurring basis | Debt
Financial Instruments and Fair Value Measurements
2023 Notes			96,089
2025 Notes	185,522		197,807
2028 Notes	204,705		211,768
Total fair value of debt	390,227		505,664
Nonrecurring basis | Quoted Price in Active Markets for Identical Assets, Level 1
Financial Instruments and Fair Value Measurements
Contingent value rights	0		0
Liabilities
Total liabilities measured at estimated fair value	0		0
Nonrecurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Debt
Financial Instruments and Fair Value Measurements
2023 Notes			0
2025 Notes	0		0
2028 Notes	0		0
Total fair value of debt	0		0
Nonrecurring basis | Significant Other Observable Inputs, Level 2
Financial Instruments and Fair Value Measurements
Contingent value rights	0		0
Liabilities
Total liabilities measured at estimated fair value	390,227		505,664
Nonrecurring basis | Significant Other Observable Inputs, Level 2 | Debt
Financial Instruments and Fair Value Measurements
2023 Notes			96,089
2025 Notes	185,522		197,807
2028 Notes	204,705		211,768
Total fair value of debt	390,227		505,664
Nonrecurring basis | Significant Unobservable Inputs, Level 3
Financial Instruments and Fair Value Measurements
Contingent value rights	595		595
Liabilities
Total liabilities measured at estimated fair value	595		595
Nonrecurring basis | Significant Unobservable Inputs, Level 3 | Debt
Financial Instruments and Fair Value Measurements
2023 Notes			0
2025 Notes	0		0
2028 Notes	0		0
Total fair value of debt	0		0
Armata | Recurring basis | Convertible Debt
Assets
Total assets measured at estimated fair value	32,838
Armata | Recurring basis | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	41,878		31,095
Armata | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	13,093		8,059
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Convertible Debt
Assets
Total assets measured at estimated fair value	0
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	41,878		31,095
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	0		0
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Convertible Debt
Assets
Total assets measured at estimated fair value	0
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	0		0
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	13,093		8,059
Armata | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible Debt
Assets
Total assets measured at estimated fair value	32,838
Armata | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	0		0
Armata | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	0		0
InCarda | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			605
InCarda | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			0
InCarda | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			0
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			605
Gate Neuroscience Member | Recurring basis | Convertible Debt
Assets
Total assets measured at estimated fair value	21,500		15,700
Gate Neuroscience Member | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Convertible Debt
Assets
Total assets measured at estimated fair value	0		0
Gate Neuroscience Member | Recurring basis | Significant Other Observable Inputs, Level 2 | Convertible Debt
Assets
Total assets measured at estimated fair value	0		0
Gate Neuroscience Member | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible Debt
Assets
Total assets measured at estimated fair value	$ 21,500		$ 15,700

[1] The investments held by ISP Fund LP consisted of $264.9 million in equity investments, which included $24.6 million in money market funds, and $53.6 million receivable from the maturity of convertible notes. Our total capital contribution of $300 million is subject to a 36-month lock-up period from the date of such capital contributions.

[2] The investments held by ISP Fund LP consisted of $295.4 million equity investments, which included private placement positions and convertible notes of $54.6 million, and $25.1 million in money market funds. Our total capital contributions of $300.0 million is subject to a 36-month lock-up period from the date of such capital contributions.