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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The amount of estimated penalties and interest accrued as of the balance sheet date arising from income tax examinations.

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Amount of operating loss carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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A roll forward is a reconciliation of a concept from the beginning of a period to the end of a period.

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The amount of the tax credit carryforward, before tax effects, available to reduce future taxable income under enacted tax laws.

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Amount of unrecognized tax benefits.

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Amount of decrease in unrecognized tax benefits resulting from tax positions taken in prior period tax returns.

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Amount of increase in unrecognized tax benefits resulting from tax positions taken in prior period tax returns.

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INCOME TAXES - Additional Tax Disclosures (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Taxes
Accrued interest and penalties	$ 0	$ 0
Uncertain Tax Positions
Unrecognized tax benefits	16,324	14,872	$ 15,185	$ 15,342
Net decrease in tax portions		$ (313)	$ (157)
Net increase in tax portions	1,452
Entasis Therapeutics Holdings Inc
Income Taxes
Federal net operating losses estimated utilization amount	157,400
La Jolla Pharmaceutical Company
Income Taxes
Federal net operating losses estimated utilization amount	254,000
Federal
Income Taxes
Net operating loss carryforwards	411,500
State
Income Taxes
Net operating loss carryforwards	955,300
State \| Research and development
Income Taxes
Tax credit carryforward amount	$ 33,300