CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Cash flows from operating activities
Net income	$ 220,262	$ 368,837	$ 293,814
Adjustments to reconcile net income to net cash provided by operating activities:
Deferred income taxes	25,006	76,432	60,420
Amortization of capitalized fees and depreciation of property and equipment	13,931	13,832	13,840
Amortization of acquired intangible assets	5,581	0	0
Fair value adjustments included in cost of product sales	10,023	0	0
Stock-based compensation	7,347	2,017	1,698
Amortization of debt discount and issuance costs	2,055	9,136	8,397
Changes in fair values of equity method investments, net	161,749	(84,392)	(49,511)
Changes in fair values of other equity and long-term investments, net	(8,462)	(4,917)	(766)
Loss on extinguishment of debt	20,662	0	0
Net gain on sale of TRC	(266,696)	0	0
Amortization of discount on short-term investments	0	0	(343)
Amortization of lease guarantee	0	0	(135)
Other non-cash items	3,402	(259)	21
Changes in operating assets and liabilities:
Accounts receivable	(3,525)	0	0
Receivables from collaborative arrangements	13,319	(16,780)	(14,504)
Inventory	280	0	0
Prepaid expenses	(21,350)	203	(678)
Other assets	(3,341)	0	0
Accounts payable	92	(39)	56
Accrued personnel-related expenses and other accrued liabilities	11,913	(257)	804
Accrued interest payable	207	0	0
Deferred revenue	(755)	0	0
Income tax payable	10,026	0	0
Net cash provided by operating activities	201,726	363,813	313,113
Cash flows from investing activities
Maturities of marketable securities	0	0	86,000
Purchases of marketable securities	0	0	(12,943)
Purchases of equity and long term investments	(58,725)	(66,278)	(87,981)
Purchases of equity investments managed by ISP Fund LP	(60,910)	(190,970)	(14,877)
Purchases of trading security managed by ISP Fund LP	(50,000)	0	0
Sales of equity investments managed by ISP Fund LP	24,281	21,440	0
Purchase and sales of other investments managed by ISP Fund LP, net	(23,371)	279,530	(285,123)
Purchases of property and equipment	(67)	0	(13)
Proceeds from sale of ownership interest in TRC, net	248,191	0	0
Cash acquired through the consolidation of Entasis	23,070	0	0
Cash paid for the acquisition of La Jolla, net of cash acquired	(159,103)	0	0
Net cash provided by (used in) investing activities	(56,634)	43,722	(314,937)
Cash flows from financing activities
Distributions to noncontrolling interest	(69,811)	(59,457)	(30,474)
Purchase of Entasis noncontrolling interest	(43,910)	0	0
Repurchase of common stock	(8,503)	(394,149)	0
Repurchase of shares to satisfy tax withholding	(82)	(60)	(92)
Proceeds from issuances of common stock	370	1,169	436
Net proceeds from the issuance of variable interest entity's equity	0	0	345
Payment for repurchase of convertible subordinated notes due 2023	(165,131)	0	0
Purchases of capped call options associated with convertible senior notes due 2028	(21,037)	0	0
Proceeds from issuance of convertible senior notes due 2028, net of issuance costs	252,536	0	0
Net cash used in financing activities	(55,568)	(452,497)	(29,785)
Net increase (decrease) in cash and cash equivalents	89,524	(44,962)	(31,609)
Cash and cash equivalents at beginning of period	201,525	246,487	278,096
Cash and cash equivalents at end of period	291,049	201,525	246,487
Supplemental disclosure of cash flow information:
Cash paid for interest	11,736	9,933	9,933
Cash paid for income taxes	53,855	0	0
Supplemental Disclosure of Non-cash Investing and Financing Activities:
Adoption of ASU 2020-06	$ (28,228)	$ 0	$ 0