CONDENSED CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common stock	Additional Paid-In Capital	Accumulated Deficit	Treasury Stock	Noncontrolling Interest	Cumulative Effect, Period of Adoption, Adjustment [Member]	Cumulative Effect, Period of Adoption, Adjustment [Member] Additional Paid-In Capital	Cumulative Effect, Period of Adoption, Adjustment [Member] Accumulated Deficit
Balance at Dec. 31, 2020	$ 607,837	$ 1,014	$ 1,260,900	$ (722,002)	$ 0	$ 67,925
Balance (in shares) at Dec. 31, 2020		101,392,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	(21,285)	$ 0	0	0	0	(21,285)
Equity activity of noncontrolling interest from a consolidated variable interest entity	8	0	0	0	0	8
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	(25)	$ 0	(25)	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		16,000
Stock-based compensation	451	$ 0	451	0	0	0
Net income	109,695	0	0	94,123	0	15,572
Balance at Mar. 31, 2021	696,681	$ 1,014	1,261,326	(627,879)	0	62,220
Balance (in shares) at Mar. 31, 2021		101,408,000
Balance at Dec. 31, 2020	607,837	$ 1,014	1,260,900	(722,002)	0	67,925
Balance (in shares) at Dec. 31, 2020		101,392,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Net income	323,187
Balance at Sep. 30, 2021	491,805	$ 695	1,262,438	(466,493)	$ (393,829)	88,994
Balance (in shares) at Sep. 30, 2021		69,492,000			32,005,000
Balance at Mar. 31, 2021	696,681	$ 1,014	1,261,326	(627,879)	$ 0	62,220
Balance (in shares) at Mar. 31, 2021		101,408,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	(20,161)	$ 0	0	0	0	(20,161)
Equity activity of noncontrolling interest from a consolidated variable interest entity	8	0	0	0	0	8
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	50	$ 1	49	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		92,000
Repurchase of common stock	(394,149)	$ (320)	0	0	$ (393,829)	0
Repurchase of common stock (in shares)		(32,005,000)			32,005,000
Stock-based compensation	470	$ 0	470	0	$ 0	0
Net income	110,846	0	0	88,948	0	21,898
Balance at Jun. 30, 2021	393,745	$ 695	1,261,845	(538,931)	$ (393,829)	63,965
Balance (in shares) at Jun. 30, 2021		69,495,000			32,005,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	(4,912)					(4,912)
Equity activity of noncontrolling interest from a consolidated variable interest entity	(267)					(267)
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	51	$ 0	51	0	$ 0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		(3,000)
Stock-based compensation	542	$ 0	542	0	0	0
Net income	102,646	0	0	72,438	0	30,208
Balance at Sep. 30, 2021	491,805	$ 695	1,262,438	(466,493)	$ (393,829)	88,994
Balance (in shares) at Sep. 30, 2021		69,492,000			32,005,000
Balance at Jun. 30, 2022	565,462	$ 697	1,183,667	(402,198)	$ (393,829)	177,125
Balance (in shares) at Jun. 30, 2022		69,706,000			32,005,000
Balance at Dec. 31, 2021	$ 525,935	$ 696	1,264,024	(456,148)	$ (393,829)	111,192	$ (28,123)	$ (65,361)	$ 37,238
Balance (in shares) at Dec. 31, 2021	69,566,000	69,566,000			32,005,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	$ (6,507)	$ 0	0	0	$ 0	(6,507)
Fair value of noncontrolling interest in a consolidated variable interest entity	38,471	0	0	0	0	38,471
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	214	$ 0	214	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		28,000
Stock-based compensation	954	$ 0	620	0	0	334
Capped call options associated with convertible senior notes due 2028	(16,585)	0	(16,585)	0	0	0
Net income	37,858	0	0	15,773	0	22,085
Balance at Mar. 31, 2022	552,217	$ 696	1,182,912	(403,137)	$ (393,829)	165,575
Balance (in shares) at Mar. 31, 2022		69,594,000			32,005,000
Balance at Dec. 31, 2021	$ 525,935	$ 696	1,264,024	(456,148)	$ (393,829)	111,192	$ (28,123)	$ (65,361)	$ 37,238
Balance (in shares) at Dec. 31, 2021	69,566,000	69,566,000			32,005,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Accounting Standards Update [Extensible Enumeration]							Accounting Standards Update 2020-06 [Member]	Accounting Standards Update 2020-06 [Member]	Accounting Standards Update 2020-06 [Member]
Net income	$ 288,576
Balance at Sep. 30, 2022	$ 641,368	$ 698	1,171,096	(136,597)	$ (393,829)	0
Balance (in shares) at Sep. 30, 2022	69,776,000	69,776,000			32,005,000
Balance at Mar. 31, 2022	$ 552,217	$ 696	1,182,912	(403,137)	$ (393,829)	165,575
Balance (in shares) at Mar. 31, 2022		69,594,000			32,005,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	(9,545)	$ 0	0	0	$ 0	(9,545)
Equity activity of noncontrolling interest from a consolidated variable interest entity	(2)	0	0	0	0	(2)
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	68	$ 1	67	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		112,000
Conversion of convertible subordinated notes due 2023	3	$ 0	3	0	0	0
Stock-based compensation	1,350	0	685	0	0	665
Net income	21,371	0	0	939	0	20,432
Balance at Jun. 30, 2022	565,462	$ 697	1,183,667	(402,198)	$ (393,829)	177,125
Balance (in shares) at Jun. 30, 2022		69,706,000			32,005,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Distributions to noncontrolling interest	(53,759)	$ 0	0	0	$ 0	(53,759)
Derecognition of noncontrolling interests upon sale of TRC	(61,226)			78	0	(61,304)
Derecognition of noncontrolling interests upon acquisition of Entasis Therapeutics Holdings Inc. ("Entasis") minority interest	(42,162)	0	(14,153)	0	0	(28,009)
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding	(11)	$ 1	(12)	0	0	0
Exercise of stock options, and issuance of common stock units and stock awards, net of repurchase of shares to satisfy tax withholding (in shares)		70,000
Stock-based compensation	3,717	$ 0	1,594	0	0	2,123
Net income	229,347	0	0	265,523	0	(36,176)
Balance at Sep. 30, 2022	$ 641,368	$ 698	$ 1,171,096	$ (136,597)	$ (393,829)	$ 0
Balance (in shares) at Sep. 30, 2022	69,776,000	69,776,000			32,005,000