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Debt - Summary (Details) - USD ($)
$ in Thousands
3 Months Ended
Sep. 30, 2022
Apr. 18, 2022
Mar. 07, 2022
Dec. 31, 2021
Debt        
Total debt $ 549,704     $ 433,484
Less: Unamortized debt discount and issuance costs (9,894)     (38,831)
Total debt, net 539,810     394,653
Less: Current portion of long-term debt, net 96,131     0
Total long-term debt, net 443,679     394,653
Deferred royalty obligation $ 75,424      
HealthCare Royalty Partners        
Debt        
Maximum potential royalty payout 14.00%      
Increase in maximum potential payout percent 4.00%      
Maximum aggregate royalty payments $ 225,000      
Required payment for breach of agreement, payment one 125,000      
Payment for royalty agreement 11,600      
2023 Notes | Convertible subordinated notes        
Debt        
Total debt 96,204 $ 96,200 $ 96,200 240,984
Less: Unamortized debt discount and issuance costs (73)   $ 200 (620)
2025 Notes        
Debt        
Unamortized debt discount       67,300
2025 Notes | Convertible senior notes        
Debt        
Total debt 192,500     192,500
Less: Unamortized debt discount and issuance costs (2,092)     (38,211)
2028 Notes | Convertible senior notes        
Debt        
Total debt 261,000     $ 0
Royalty Financing Agreement | Loans Payable [Member] | HealthCare Royalty Partners        
Debt        
Interest expense 1,500      
Deferred royalty obligation 79,900      
Unamortized debt discount 500      
Royalty Obligation Payable 75,400      
Short term accrued interest 4,500      
Royalty Payments $ 1,000