Financial Instruments and Fair Value Measurements - Schedule of Available-for-Sale Securities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	9 Months Ended		12 Months Ended
	Sep. 30, 2022		Dec. 31, 2021
Fair Value Measurements
Contingent value rights	$ 294
ISP Fund LP
Liabilities
Lock-up period	36 months		36 months
Contributed to partnership for investing	$ 300,000
Cash | ISP Fund LP
Assets
Total assets measured at estimated fair value	5,100
Money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	38,700		$ 3,500
Equity investment | ISP Fund LP
Assets
Total assets measured at estimated fair value	246,000		192,200
Private Placement Positions and Convertible Notes | ISP Fund LP
Assets
Total assets measured at estimated fair value	53,200
Recurring basis
Assets
Total assets measured at estimated fair value	730,926		606,792
Recurring basis | Money market funds
Assets
Total assets measured at estimated fair value	261,718		145,132
Recurring basis | Short-term marketable securities
Assets
Total assets measured at estimated fair value	282
Recurring basis | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	289,787	[1]	195,745	[2]
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1
Assets
Total assets measured at estimated fair value	604,448		489,704
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Money market funds
Assets
Total assets measured at estimated fair value	261,718		145,132
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Short-term marketable securities
Assets
Total assets measured at estimated fair value	282
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	236,624	[1]	193,677	[2]
Recurring basis | Significant Other Observable Inputs, Level 2
Assets
Total assets measured at estimated fair value	50,605		99,509
Recurring basis | Significant Unobservable Inputs, Level 3
Assets
Total assets measured at estimated fair value	75,873		17,579
Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	53,163	[1]	2,068	[2]
Nonrecurring basis
Fair Value Measurements
Contingent value rights	294
Liabilities
Total liabilities measured at estimated fair value	482,577
Nonrecurring basis | Debt
Fair Value Measurements
2023 Notes	95,001		261,769
2025 Notes	185,041		234,498
2028 Notes	202,241
Total fair value of debt	482,283		496,267
Nonrecurring basis | Significant Other Observable Inputs, Level 2
Liabilities
Total liabilities measured at estimated fair value	482,283
Nonrecurring basis | Significant Other Observable Inputs, Level 2 | Debt
Fair Value Measurements
2023 Notes	95,001		261,769
2025 Notes	185,041		234,498
2028 Notes	202,241
Total fair value of debt	482,283		496,267
Nonrecurring basis | Significant Unobservable Inputs, Level 3
Fair Value Measurements
Contingent value rights	294
Liabilities
Total liabilities measured at estimated fair value	294
Armata | Recurring basis | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	105,824		88,101
Armata | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	50,605		58,595
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	105,824		88,101
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	50,605		58,595
Entasis Therapeutics Holdings Inc | Recurring basis | Equity investment | Common stock
Assets
Total assets measured at estimated fair value			62,794
Entasis Therapeutics Holdings Inc | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			40,914
Entasis Therapeutics Holdings Inc | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value			62,794
Entasis Therapeutics Holdings Inc | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			40,914
InCarda | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			411
InCarda | Recurring basis | Equity investment | Series C preferred stock
Assets
Total assets measured at estimated fair value	6,809
InCarda | Recurring basis | Equity investment | Preferred Stock Warrants
Assets
Total assets measured at estimated fair value	501
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			411
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Series C preferred stock
Assets
Total assets measured at estimated fair value	6,809
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Preferred Stock Warrants
Assets
Total assets measured at estimated fair value	501
Gate Neuroscience Member | Recurring basis | Convertible Debt Member
Assets
Total assets measured at estimated fair value	15,400		15,100
Gate Neuroscience Member | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible Debt Member
Assets
Total assets measured at estimated fair value	$ 15,400		$ 15,100

[1] The investments held by ISP Fund LP, consisted of $246.0 million in equity investments, which included private placement positions and convertible notes of $53.2 million, $38.7 million in money market funds and $5.1 million in cash. Our total capital contribution of $300.0 million is subject to a 36-month lock-up period from the date of such capital contributions.

[2] The investments held by ISP Fund LP, consisted of $192.2 million equity investments and $3.5 million money market funds, are subject to a 36-month lock-up period from our initial contribution date, December 11, 2020.