Financial Instruments and Fair Value Measurements - Schedule of Available-for-Sale Securities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2022		Dec. 31, 2021
ISP Fund LP
Assets
Lock-up period	36 months		36 months
Contributed to partnership for investing	$ 300,000
Cash | ISP Fund LP
Assets
Total assets measured at estimated fair value	110,300
Money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	25,200		$ 3,500
Equity investment | ISP Fund LP
Assets
Total assets measured at estimated fair value	172,100		192,200
Private Placement Positions | ISP Fund LP
Assets
Total assets measured at estimated fair value	2,100
Recurring basis
Assets
Total assets measured at estimated fair value	614,868		606,792
Recurring basis | Money market funds
Assets
Total assets measured at estimated fair value	103,181		145,132
Recurring basis | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	307,576	[1]	195,745	[2]
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1
Assets
Total assets measured at estimated fair value	531,322		489,704
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Money market funds
Assets
Total assets measured at estimated fair value	103,181		145,132
Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	305,516	[1]	193,677	[2]
Recurring basis | Significant Other Observable Inputs, Level 2
Assets
Total assets measured at estimated fair value	64,894		99,509
Recurring basis | Significant Unobservable Inputs, Level 3
Assets
Total assets measured at estimated fair value	18,652		17,579
Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investments and money market funds | ISP Fund LP
Assets
Total assets measured at estimated fair value	2,060	[1]	2,068	[2]
Nonrecurring basis | Debt
Fair Value Measurements
2023 Notes	106,499		261,769
2025 Notes	253,497		234,498
2028 Notes	260,815
Total fair value of debt	620,811		496,267
Nonrecurring basis | Significant Other Observable Inputs, Level 2 | Debt
Fair Value Measurements
2023 Notes	106,499		261,769
2025 Notes	253,497		234,498
2028 Notes	260,815
Total fair value of debt	620,811		496,267
Armata | Recurring basis | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	122,625		88,101
Armata | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	64,894		58,595
Armata | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value	122,625		88,101
Armata | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	64,894		58,595
Entasis Therapeutics Holdings Inc | Recurring basis | Equity investment | Common stock
Assets
Total assets measured at estimated fair value			62,794
Entasis Therapeutics Holdings Inc | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			40,914
Entasis Therapeutics Holdings Inc | Recurring basis | Quoted Price in Active Markets for Identical Assets, Level 1 | Equity investment | Common stock
Assets
Total assets measured at estimated fair value			62,794
Entasis Therapeutics Holdings Inc | Recurring basis | Significant Other Observable Inputs, Level 2 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value			40,914
InCarda | Recurring basis | Convertible Debt Member
Assets
Total assets measured at estimated fair value	652
InCarda | Recurring basis | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	1,040		411
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible Debt Member
Assets
Total assets measured at estimated fair value	652
InCarda | Recurring basis | Significant Unobservable Inputs, Level 3 | Equity investment | Warrants
Assets
Total assets measured at estimated fair value	1,040		411
Gate Neuroscience Member | Recurring basis | Convertible Debt Member
Assets
Total assets measured at estimated fair value	14,900		15,100
Gate Neuroscience Member | Recurring basis | Significant Unobservable Inputs, Level 3 | Convertible Debt Member
Assets
Total assets measured at estimated fair value	$ 14,900		$ 15,100

[1] The investments held by ISP Fund LP, consisted of $172.1 million in equity investments, which included $2.1 million in a private placement position, $25.2 million in money market funds and $110.3 million in cash. Our total capital contribution of $300.0 million is subject to a 36-month lock-up period from the date of such capital contributions.

[2] The investments held by ISP Fund LP, consisted of $192.2 million equity investments and $3.5 million money market funds, are subject to a 36-month lock-up period from our initial contribution date, December 11, 2020.