Commitments and Contingencies - Additional Information (Detail)	12 Months Ended
	Dec. 31, 2015 USD ($) ft²	Dec. 31, 2014 USD ($)	Dec. 31, 2013 USD ($)
Commitments And Contingencies Disclosure [Abstract]
Operating leases expiration period	2020-12
Square Feet of Office and Laboratory | ft²	49,000
Rent expenses	$ 1,900,000	$ 1,700,000	$ 1,100,000
Purchase commitments expiration period	2019-10
Capital lease expiration year	2019
Weighted Average Interest Rates	8.04%
Base salaries expected in 2016	$ 2,147,000