CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (30,795)	$ (49,408)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	9,048	8,395
Amortization of intangibles	8,783	8,490
Non-cash stock-based compensation	4,758	12,103
Non-cash operating lease expense	2,330	2,653
Amortization of convertible debt discount	669	661
Amortization of debt issue costs	46	45
Gain on sale of assets held for sale	0	(2,048)
Impairment of assets	923	0
Other adjustments	(31)	1,126
Changes in assets and liabilities, net
Accounts receivable, net	870	1,334
Inventories	(200)	(445)
Prepaid and other assets	(1,187)	(2,044)
Operating lease liabilities	(1,722)	(2,832)
Deferred income tax liabilities, net	(3,035)	(3,765)
Accrued compensation	(7,250)	(5,985)
Accounts payable and other liabilities	4,101	2,680
Net cash used in operating activities	(12,692)	(29,040)
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of marketable securities	(6,756)	(16,167)
Proceeds from sales and maturities of marketable securities	40,425	36,438
Purchases of property and equipment	(9,927)	(8,219)
Net cash provided by investing activities	23,742	12,052
CASH FLOWS FROM FINANCING ACTIVITIES
Repayment of equipment financing obligations	(32)	(346)
Issuance of common stock, net	1,411	6,403
Net cash provided by financing activities	1,379	6,057
Net change in cash and cash equivalents	12,429	(10,931)
Cash and cash equivalents, beginning of period	263,180	316,827
Cash and cash equivalents, end of period	275,609	305,896
Supplemental disclosure of cash flow information:
Interest paid	432	442
Supplemental disclosure of non-cash investing and financing information:
Increase in other current assets for the sale of assets held for sale	0	12,098
Purchases of property and equipment included in accounts payable	$ 1,174	$ 1,061