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Liquidity (Details Narrative) - USD ($)
$ / shares in Units, $ in Thousands
Apr. 10, 2018
Jun. 30, 2019
Dec. 31, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]      
Accumulated deficit   $ (391,229) $ (342,864)
Cash and cash equivalents and short-term investments   $ 58,200  
Public offering share value 3,418,918    
Common stock, par value $ 0.001 $ .001 $ .001
Public offering price per share $ 8.51    
Proceeds for public offering $ 27,900