CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2017	Sep. 30, 2016	Sep. 30, 2017	Sep. 30, 2016
Revenues:
Research and other	$ 148	$ 159	$ 304	$ 552
Total revenues	148	159	304	552
Operating costs and expenses:
Research and development	9,721	21,094	20,222	43,247
General and administrative	2,965	2,668	9,254	7,929
Legal expenses	1,595	1,913	7,530	7,394
Total operating costs and expenses	14,281	25,675	37,006	58,570
Loss from operations	(14,133)	(25,516)	(36,702)	(58,018)
Other income (expense):
Inducement loss	(2,297)	(1,457)	(2,297)	(1,457)
Change in fair value of derivative liabilities	(4,933)	(217)	2,963	17,238
Net loss from extinguishment of debt	(1,975)	(433)	(10,517)	(433)
Interest expense	(1,193)	(691)	(3,695)	(2,138)
Foreign currency transaction gain (loss)	1,260	(913)	4,104	(4,700)
Net loss	(23,271)	(29,227)	(46,144)	(49,508)
Deemed dividend related to warrant modification	0	(3,007)	0	(5,647)
Net loss applicable to common stockholders	$ (23,271)	$ (32,234)	$ (46,144)	$ (55,155)
Net loss per share applicable to common stockholders - basic and diluted (in dollars per share)	$ (0.08)	$ (0.28)	$ (0.21)	$ (0.52)
Weighted average shares used in computing basic and diluted loss per share (in shares)	281,486	114,836	217,587	105,501