Income Taxes (Tables)

12 Months Ended

Dec. 31, 2016

Schedule of Deferred Tax Assets and Liabilities [Table Text Block]

The tax effects of temporary differences and tax loss and credit carry forwards that give rise to significant portions of deferred tax assets and liabilities at December 31, 2016 and 2015 are comprised of the following (in thousands):

	As of December 31,
	2016		2015
Deferred tax asset
Net operating loss carryforward	$	204,106	$	180,927
Research and development credit carry forwards		14,911		12,661
Stock based compensation and other		17,106		24,759
Total deferred tax assets		236,123		218,347
Valuation Allowance		(236,123)		(218,347)
Deferred tax asset, net of allowance	$	-	$	-

Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]

The expected tax expense (benefit) based on the U.S. federal statutory rate is reconciled with actual tax expense (benefit) as follows:

(dollars in thousands)

	For the years ended
	2016			2015
Statutory federal income tax rate		34.0	%		34.0	%
State taxes, net of federal tax benefit		1.8	%		5.4	%
Tax rate differential on foreign income		-2.3	%		0.0	%
Derivative gain or loss and other		7.6	%		5.8	%
Cancellation of shares		-16.6	%		0.0	%
Cancellation of warrants		-7.8	%		0.0	%
Other permanent items and true ups		2.7	%		0.0	%
R&D Credit		2.8	%		2.6	%
Change in valuation allowance		-22.2	%		-47.8	%
Income tax provision (benefit)		0.0	%		0.0	%

Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]

	For the years ended
	2016		2015
Federal
Current	$	-	$	-
Deferred		(11,160)		(41,583)
State
Current		-		-
Deferred		(1,427)		(6,659)
Foreign
Current		-		-
Deferred		(5,189)		-
Change in valuation allowance		17,776		48,242
Income tax provision (benefit)	$	-	$	-