Exhibit 21

List of Subsidiaries

AirLogix, Inc., a Delaware corporation

Bankers Reserve Life Insurance Company of Wisconsin, a Wisconsin corporation

Buckeye Community Health Plan, Inc., an Ohio corporation

CCTX Holdings, LLC, a Delaware LLC

CenCorp Consulting Company, Inc., a Delaware corporation

Cenphiny Management, LLC, a Delaware LLC

Cenpatico Behavioral Health, LLC, a California LLC

Cenpatico Behavioral Health of Texas, Inc., a Texas corporation

Centene Company of Texas, LP, a Texas limited partnership

Centene Finance Corporation, a Delaware corporation *

Centene Holdings, LLC, a Delaware LLC

Centene Management Company, LLC, a Wisconsin LLC

Centene Plaza Redevelopment Corporation, a Missouri corporation

CMC Real Estate Company, LLC, a Delaware LLC

Coordinated Care Corporation Indiana, Inc., d/b/a Managed Health Services, an Indiana corporation

FirstGuard, Inc., a Delaware corporation

FirstGuard Health Plan, Inc., a Missouri corporation

FirstGuard Health Plan Kansas, Inc., a Kansas corporation

Managed Health Services Illinois, Inc., an Illinois corporation *

Managed Health Services Insurance Corporation, a Wisconsin corporation

MHS Consulting Corporation, a Wisconsin corporation

NurseWise Holdings, LLC, a Delaware LLC

NurseWise, LP, a Delaware limited partnership

Peach State Health Plan, Inc., a Georgia corporation

Superior HealthPlan, Inc., a Texas corporation

University Health Plans, Inc., a New Jersey corporation

U.S. Script, Inc., a Delaware corporation

* Inactive subsidiary