Exhibit 21

List of Subsidiaries

AirLogix, Inc., a Delaware corporation

Bankers Reserve Life Insurance Company of Wisconsin, a Wisconsin corporation

Bridgeway Health Solutions, LLC, a Delaware LLC

Buckeye Community Health Plan, Inc., an Ohio corporation

Cardium Health Services Corporation, a Delaware corporation

CCTX Holdings, LLC, a Delaware LLC

CenCorp Consulting Company, Inc., a Delaware corporation

Cenpatico Behavioral Health, LLC, a California LLC

Cenphiny Management, LLC, a Delaware LLC

Centene Company of Texas, LP, a Texas limited partnership

Centene Holdings, LLC, a Delaware LLC

Centene Management Company, LLC, a Wisconsin LLC

Centene Plaza Redevelopment Corporation, a Missouri corporation

CMC Real Estate Company, LLC, a Delaware LLC

Coordinated Care Corporation Indiana, Inc., d/b/a Managed Health Services, an Indiana corporation

FirstGuard Health Plan Kansas, Inc., a Kansas corporation

FirstGuard Health Plan, Inc., a Missouri corporation

FirstGuard, Inc., a Delaware corporation

Managed Health Services Insurance Corporation, a Wisconsin corporation

MHS Consulting Corporation, Inc., a Wisconsin corporation

NurseWise Holdings, LLC, a Delaware LLC

NurseWise, LP, a Delaware limited partnership

OptiCare Managed Vision, Inc., a Delaware corporation

Peach State Health Plan, Inc., a Georgia corporation

Superior HealthPlan, Inc., a Texas corporation

U.S. Script, Inc., a Delaware corporation

University Health Plans, Inc., a New Jersey corporation