Condensed Consolidated Statements of Operations (Unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended
	Mar. 31, 2020	Mar. 31, 2019
Revenues
Type of Revenue [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember
Total revenues	$ 90,068	$ 62,959
Operating expenses
Type of Cost, Good or Service [Extensible List]	us-gaap:ProductMember	us-gaap:ProductMember
Cost of product sales	$ 2,799	$ 2,950
License fees and royalties	2,175	1,630
Research and development	72,636	52,923
Selling, general and administrative	101,973	93,090
Total operating expenses	179,583	150,593
Loss from operations	(89,515)	(87,634)
Interest income, net	2,989	2,934
Other expense	(1,497)	(229)
Loss before income taxes	(88,023)	(84,929)
Income tax expense		375
Net loss	$ (88,023)	$ (85,304)
Net loss per common share, basic and diluted	$ (0.57)	$ (0.59)
Weighted average common shares outstanding, basic and diluted	155,368	143,981