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Balance Sheet Details - Schedule of Accrued Liabilities (Detail) - USD ($)
$ in Thousands
Mar. 31, 2017
Dec. 31, 2016
Payables And Accruals [Abstract]    
Accrued consulting and professional fees $ 13,582 $ 9,488
Accrued compensation and benefits 11,509 14,382
Accrued research and development services 7,570 8,551
Other 6,306 3,608
Accrued liabilities $ 38,967 $ 36,029