Commitments and Contingencies - Additional Information (Detail) (USD $)	1 Months Ended		12 Months Ended
	Apr. 30, 2011	Jun. 30, 2005	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Nov. 30, 2006
Supply Commitment [Line Items]
Operating lease, expiration year			2016-12
Rent expense			$ 594,000	$ 663,000	$ 2,100,000
Operating lease term, years		10 years
One time payment of lease related obligation	690,000
Common stock issued for settlement of lease related obligations	782,339
General and administrative expense	1,100,000		12,720,000	6,999,000	7,610,000
Lease termination charges	1,700,000
Reduction in cumulative translation adjustment balance related to liquidation of substantially all assets of Swedish subsidiary	539,000
Potential future milestones payments to agreement with Ipsen Group						10,500,000
Maximum
Supply Commitment [Line Items]
Development services			$ 19,100,000