Income Taxes - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Income Tax [Line Items]
Operating loss carryforwards	$ 100,000
State income tax provision	400,000	$ 400,000	$ 900,000
Foreign Income Tax Expense (Benefit)		200,000
Charitable contribution carryforwards	41,355,000	28,470,000
Federal R&D credit carryforwards	65,800,000
Increase in valuation allowance of deferred tax assets	36,100,000
Deferred tax asset , Switzerland tax reform			57,000,000.0
Unrecognized tax reserves recorded during period	4,100,000	2,900,000	1,900,000
Interest and/or penalties accrued	0	0
Interest and/or penalties	0	$ 0	$ 0
Expire in 2022
Income Tax [Line Items]
Federal R&D credit carryforwards	300,000
Federal
Income Tax [Line Items]
Operating loss carryforwards	551,200,000
Federal | Expiring in 2025
Income Tax [Line Items]
Operating loss carryforwards	6,900,000
State
Income Tax [Line Items]
Operating loss carryforwards	426,200,000
Remaining net operating loss carryforward, expiration year		2026
Charitable contribution carryforwards	171,300,000
Research and development credit carryforwards with no expiration date	18,500,000
State | Expiring in 2024
Income Tax [Line Items]
Net operating loss carryforwards with no expiration date	2,800,000
State | Expiring in 2022
Income Tax [Line Items]
Charitable contribution carryforwards	21,800,000
Foreign
Income Tax [Line Items]
Operating loss carryforwards	1,354,300,000
Remaining net operating loss carryforward, expiration year		2026
Net operating loss carryforwards with no expiration date	3,400,000
Foreign | Operating Loss Carryforwards Expiring 2022
Income Tax [Line Items]
Operating loss carryforwards	$ 218,500,000