Fair value of financial instruments and investments - Fair Value Liabilities Measured (Details) - Agilis $ in Thousands	Mar. 31, 2024 USD ($)	Dec. 31, 2023 USD ($)	Mar. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)
Significant unobservable inputs (Level 3) | Upstaza
Fair Value Valuation Inputs
Fair value	$ 36,200
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Minimum
Fair Value Valuation Inputs
Potential milestones	0	$ 0
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Development and Regulatory Milestone | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 31,000	$ 31,000
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.85	0.85
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.92	0.92
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.059	0.058
Development and Regulatory Milestones | Commitments | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.062	0.061
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.90
Development and Regulatory Milestones | Upstaza | Commitments | Valuation Technique, Discounted Cash Flow | Measurement Input, Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.060
Development and Regulatory Milestones | Significant unobservable inputs (Level 3) | Commitments
Fair Value Valuation Inputs
Fair value	$ 26,900	$ 26,600	$ 85,500	$ 82,500
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Minimum
Fair Value Valuation Inputs
Potential milestones	0	0
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Sales Milestones | Maximum
Fair Value Valuation Inputs
Potential milestones	$ 50,000	$ 50,000
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Minimum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.85	0.85
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Maximum
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	1	1
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Percentage of Sales for Royalties
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0	0
Net Sales Milestones and Royalties | Commitments | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.135	0.11
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Probability of Success | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.93
Net Sales Milestones and Royalties | Upstaza | Commitments | Valuation Technique, Option Pricing Model | Measurement Input, Discount Rate | Weighted Average
Fair Value Valuation Inputs
Rights Exchange Settlement measurement	0.135
Net Sales Milestones and Royalties | Significant unobservable inputs (Level 3) | Commitments
Fair Value Valuation Inputs
Fair value	$ 9,300	$ 9,700	$ 80,900	$ 81,500