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Summary of significant accounting policies - Narrative (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Dec. 22, 2017
Jun. 30, 2022
USD ($)
Jul. 31, 2020
USD ($)
Mar. 31, 2023
USD ($)
segment
country
Mar. 31, 2022
USD ($)
country
segment
Dec. 31, 2019
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Credit agreement reserve       $ 50,000        
Number of operating segments | segment       1 1      
Allowance for credit loss       $ 0 $ 0      
Increase in allowance for credit losses       0 0      
Allowance for doubtful accounts receivable       400     $ 300  
Revenue       220,382 $ 148,735      
Cash consideration received from Royalty Purchase Agreement     $ 650,000          
Income taxes                
Federal income tax statutory rate 21.00%              
Federal income tax provision - IRC Section 174 R&D Expenses       700        
State income tax provision - IRC Section 174 R&D Expenses       2,900        
Agilis                
Income taxes                
Deferred tax liability               $ 122,000
Deposits and other assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Bank guarantee       500        
Blackstone Credit Agreement                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Credit agreement reserve       $ 50,000        
Hopewell Campus                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Period after which letter of credit may be reduced if lease is not in default           5 years    
Hopewell Campus | Minimum                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Term for letter of credit (in years)           5 years    
Hopewell Campus | Deposits and other assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit           $ 7,500    
Hopewell Campus | Fifth Anniversary                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit           $ 3,800    
Warren Premises                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Period after which letter of credit may be reduced if lease is not in default   5 years            
Warren Premises | Deposits and other assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit   $ 8,100            
Warren Premises | Fifth Anniversary                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit   $ 4,100            
Net product revenue | Geographic concentration risk                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Number of countries exceeding 10% of net product sales | country       3 2      
Percentage of net product sales threshold       10.00% 10.00%      
Net product revenue | Geographic concentration risk | Russia                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       $ 44,600        
Net product revenue | Geographic concentration risk | Brazil                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       25,900 $ 25,800      
Net product revenue | Geographic concentration risk | United States                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       54,600 48,600      
Net product revenue                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       187,557 129,832      
Net product revenue | Non-US                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       133,000 81,200      
Emflaza | United States                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       54,600 48,600      
Translarna | Non-US                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       $ 115,100 $ 79,200