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Income taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)
$ in Thousands
Dec. 31, 2022
Dec. 31, 2021
Deferred tax assets:    
Accrued expense $ 2,124 $ 8,208
Amortization 52,532 87,998
Federal tax credits 174,802 142,595
State tax credits 9,787 8,054
Federal net operating losses 69,957 76,589
State net operating losses 10,316 9,159
Foreign net operating losses 4,837 3,316
Capitalized research and development costs 110,219 241
Share based compensation and other 27,054 15,273
Liability for sale of future royalties 185,589 148,503
Noncash interest expense 30,160 26,040
Other comprehensive loss (719) 143
Total gross deferred tax assets 676,658 526,119
Less valuation allowance (672,172) (525,570)
Total deferred tax assets, net of valuation allowance 4,486 549
Deferred tax liabilities:    
Depreciation (4,486) (549)
Indefinite lived intangible (102,834) (137,110)
Total gross deferred tax liabilities (107,320) (137,659)
Net deferred tax assets (liabilities) $ (102,834) $ (137,110)