XML 63 R41.htm IDEA: XBRL DOCUMENT v3.22.4
Summary of significant accounting policies - Narrative (Details)
$ in Thousands
1 Months Ended 3 Months Ended 12 Months Ended
Jun. 30, 2022
USD ($)
Jul. 31, 2020
USD ($)
Dec. 31, 2022
USD ($)
Dec. 31, 2022
USD ($)
segment
country
Dec. 31, 2021
USD ($)
country
Dec. 31, 2020
USD ($)
country
Dec. 31, 2019
USD ($)
Dec. 31, 2018
USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit             $ 7,500  
Number of operating segments | segment       1        
Number of reporting units | segment       1        
Allowance for credit loss     $ 0 $ 0 $ 0      
Allowance for doubtful accounts receivable     300 300 100      
Revenue       698,801 538,593 $ 380,766    
Cash consideration received from Royalty Purchase Agreement   $ 650,000       650,000    
State income tax provision       $ 4,224 $ 3,844 $ 24,984    
Income taxes                
Federal income tax statutory rate       21.00% 21.00% 21.00%    
Deferred tax liability     107,320 $ 107,320 $ 137,659      
Impairment of long-lived assets       0        
Non cash realized foreign exchange loss       16,887        
Increase in current taxable income resulting from the elimination of current deduction of qualifying R&D costs under Section 174.       450,100        
Impairment of indefinite-lived intangibles excluding goodwill       33,384        
Impairment of goodwill       0        
Minimum                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Term for letter of credit (in years)             5 years  
Indefinite-lived intangible assets                
Income taxes                
Impairment of indefinite-lived intangibles excluding goodwill       33,384        
Indefinite-lived intangible assets | Upstaza                
Income taxes                
Impairment of indefinite-lived intangibles excluding goodwill     33,400 33,384        
Agilis                
Income taxes                
Deferred tax liability               $ 122,000
Impairment of goodwill       0        
Prepaids and other current assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Deferred research and development advance payments, short-term     2,400 2,400 1,400      
Deposits and other assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Bank guarantee     500 500        
Deferred research and development advance payments, long-term     $ 3,900 3,900 1,800      
Fifth Anniversary                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit             $ 3,800  
Term for letter of credit (in years)             5 years  
Warren Premises                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Period after which letter of credit may be reduced if lease is not in default 5 years              
Warren Premises | Deposits and other assets                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit $ 8,100              
Warren Premises | Fifth Anniversary                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Letters of credit $ 4,100              
Non-US                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       200,234 241,588      
United States                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       $ 498,567 $ 297,005      
Net product revenue | Geographic concentration risk                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Number of countries exceeding 10% of net product sales | country       2 1 1    
Percentage of net product sales threshold       10.00% 10.00% 10.00%    
Net product revenue                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       $ 535,228 $ 428,904 $ 333,401    
Net product revenue | Non-US                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       316,900 241,600 194,400    
Net product revenue | Net product revenue | Geographic concentration risk | Russia                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       59,700        
Net product revenue | Net product revenue | Geographic concentration risk | United States                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       218,300        
Emflaza | United States                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       218,300 187,300 139,000    
Translarna | Non-US                
New Accounting Pronouncements or Change in Accounting Principle [Line Items]                
Revenue       $ 288,600 $ 236,000 $ 191,900