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Consolidated Statements of Operations - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Revenues:      
Revenue $ 698,801 $ 538,593 $ 380,766
Operating expenses:      
Cost of product sales, excluding amortization of acquired intangible assets 44,678 32,328 18,942
Amortization of intangible assets 116,554 54,751 36,892
Research and development 651,496 540,684 477,643
Selling, general and administrative 325,998 285,773 245,164
Change in the fair value of deferred and contingent consideration (25,900) (500) 23,280
Intangible asset impairment 33,384    
Settlement of deferred and contingent consideration     10,613
Total operating expenses 1,146,210 913,036 812,534
Loss from operations (447,409) (374,443) (431,768)
Interest expense, net (90,871) (86,022) (56,352)
Other (expense) income, net (49,207) (57,875) 85,188
Loss before income tax expense (587,487) (518,340) (402,932)
Income tax benefit (expense) 28,470 (5,561) (35,228)
Net loss attributable to common stockholders $ (559,017) $ (523,901) $ (438,160)
Weighted-average shares outstanding:      
Basic 71,728,634 70,466,393 66,027,908
Diluted 71,728,634 70,466,393 66,027,908
Net loss per share-basic and diluted (in dollars per share)      
Basic $ (7.79) $ (7.43) $ (6.64)
Diluted $ (7.79) $ (7.43) $ (6.64)
Net product revenue      
Revenues:      
Revenue $ 535,228 $ 428,904 $ 333,401
Collaboration revenue      
Revenues:      
Revenue 50,052 55,046 42,579
Royalty revenue      
Revenues:      
Revenue $ 113,521 $ 54,643 $ 4,786