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Consolidated Statements of Operations - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Revenues:    
Revenue $ 117,942 $ 68,259
Operating expenses:    
Cost of product sales, excluding amortization of acquired intangible assets 9,104 4,085
Amortization of acquired intangible assets 11,278 7,949
Research and development 134,513 90,107
Selling, general and administrative 61,095 58,209
Change in the fair value of deferred and contingent consideration 100 900
Total operating expenses 216,090 161,250
Loss from operations (98,148) (92,991)
Interest expense, net (19,159) (5,642)
Other expense, net (10,884) (13,832)
Loss before income tax expense (128,191) (112,465)
Income tax expense (451) (222)
Net loss attributable to common stockholders $ (128,642) $ (112,687)
Weighted-average shares outstanding:    
Basic and diluted (in shares) 70,188,602 62,389,158
Net loss per share-basic and diluted (in dollars per share)    
Net loss per share-basic and diluted (in dollars per share) $ (1.83) $ (1.81)
Net product revenue    
Revenues:    
Revenue $ 91,280 $ 68,196
Collaboration revenue    
Revenues:    
Revenue 20,007 63
Royalty revenue    
Revenues:    
Revenue $ 6,655 $ 0