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Selected quarterly financial data (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2020
Sep. 30, 2020
Jun. 30, 2020
Mar. 31, 2020
Dec. 31, 2019
Sep. 30, 2019
Jun. 30, 2019
Mar. 31, 2019
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Disaggregation of Revenue [Line Items]                      
Revenue                 $ 380,766 $ 306,980 $ 264,734
Operating Expenses $ 215,238 $ 173,535 $ 262,512 $ 161,250 $ 169,243 $ 131,891 $ 124,280 $ 122,723 812,534 548,138 380,419
Loss from operations (96,374) (55,131) (187,273) (92,991) (72,784) (60,475) (38,758) (69,140) (431,768) (241,158) (115,685)
Net loss attributable to common stockholders $ (74,354) $ (69,692) $ (181,427) $ (112,687) $ (77,677) $ (59,997) $ (41,789) $ (72,113) $ (438,160) $ (251,576) $ (128,081)
Basic and diluted (in dollars per share) $ (1.08) $ (1.03) $ (2.78) $ (1.81) $ (1.37) $ (1.06) $ (0.75) $ (1.29) $ (6.64) $ (4.27) $ (2.75)
Net product revenue                      
Disaggregation of Revenue [Line Items]                      
Revenue $ 107,258 $ 82,708 $ 75,239 $ 68,196 $ 81,407 $ 71,369 $ 85,476 $ 53,054 $ 333,401 $ 291,306 $ 263,005
Collaboration revenue                      
Disaggregation of Revenue [Line Items]                      
Revenue 7,516 35,000   $ 63 $ 15,052 $ 47 $ 46 $ 529 42,579 $ 15,674 $ 1,729
Royalty revenue                      
Disaggregation of Revenue [Line Items]                      
Revenue $ 4,090 $ 696             $ 4,786