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Income taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)
$ in Thousands
Dec. 31, 2020
Dec. 31, 2019
Deferred tax assets:    
Accrued expense $ 5,528 $ 2,588
Amortization 80,677 78,291
Depreciation   991
Federal tax credits 123,405 99,421
State tax credits   6,489
Federal net operating losses 16,999 91,010
State net operating losses 1,428 1,360
Foreign net operating losses   1,056
Capitalized research and development costs 661 1,274
Share based compensation and other 14,612 16,425
Liability for sale of future royalties 161,204  
Other comprehensive loss 7,624 1,512
Total gross deferred tax assets 412,138 300,417
Less valuation allowance (379,608) (267,131)
Total deferred tax assets, net of valuation allowance 32,530 33,286
Deferred tax liabilities:    
Depreciation (2,904)  
Convertible debt (29,626) (33,286)
Indefinite lived intangible (136,735) (130,862)
Total gross deferred tax liabilities (169,265) (164,148)
Net deferred tax assets (liabilities) $ (136,735) $ (130,862)