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The Company (Details) - USD ($)
$ in Thousands
12 Months Ended
Apr. 29, 2020
Aug. 23, 2018
Dec. 31, 2020
Dec. 31, 2019
Sep. 30, 2019
Aug. 31, 2015
Long-term debt            
Contingent liability, cancellation and forfeiture $ 211,600          
Retained earnings (accumulated deficit)     $ (1,628,877) $ (1,190,499)    
Convertible debt | 1.50% Convertible senior notes due 2026            
Long-term debt            
Interest rate ( as a percent )         1.50%  
Convertible debt | 3.00% Convertible senior notes due 2022            
Long-term debt            
Interest rate ( as a percent )           3.00%
Rights Exchange Agreement            
Long-term debt            
Shares issued under Rights Exchange Agreement 2,821,176   2,821,176      
Cash consideration payment under Rights Exchange Agreement $ 36,900   $ 36,900      
Agilis            
Long-term debt            
Payments for asset acquisitions   $ 49,221        
Equity Interest Issued, number of shares (in shares)   3,500,907        
Numerator for calculation of number of shares of equity interests issued to acquire entity   $ 150,000        
Trading day period   10 days        
Development milestone payments which the entity is obligated to pay     $ 40,000      
Net sales amount $ 150,000          
Agilis | Minimum            
Long-term debt            
Product sales (as a percent) 2.00%   2.00%      
Agilis | Maximum            
Long-term debt            
Development milestone payments which the entity is obligated to pay $ 20,000          
Priority review voucher amount     $ 535,000      
Development milestone payment obligations, net of cancellation and forfeiture     20,000      
Contingent liability, milestone, potential achievements, priority review voucher amount, net of cancellation and forfeiture 361,000   361,000      
Net sales amount $ 150,000   $ 150,000      
Product sales (as a percent) 6.00%   6.00%      
Agilis | Agilis Merger Agreement | Maximum            
Long-term debt            
Priority review voucher amount     $ 535,000      
Agilis | Rights Exchange Agreement            
Long-term debt            
Contingent liability, cancellation and forfeiture     $ 211,600