Consolidated Statements of Operations (unaudited) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2020	Sep. 30, 2019	Sep. 30, 2020	Sep. 30, 2019
Revenues:
Revenue	$ 118,404	$ 71,416	$ 261,902	$ 210,521
Operating expenses:
Cost of product sales, excluding amortization of acquired intangible assets	4,667	3,006	14,056	8,593
Amortization of acquired intangible assets	9,630	7,025	26,309	19,677
Research and development	92,998	63,076	359,630	175,621
Selling, general and administrative	57,840	49,284	169,708	139,044
Change in the fair value of deferred and contingent consideration	8,400	9,500	16,980	35,960
Settlement of deferred and contingent consideration	0	0	10,613	0
Total operating expenses	173,535	131,891	597,296	378,895
Loss from operations	(55,131)	(60,475)	(335,394)	(168,374)
Interest expense, net	(21,039)	(2,666)	(32,060)	(7,028)
Other income, net	28,766	2,800	26,242	2,509
Loss before income tax expense	(47,404)	(60,341)	(341,212)	(172,893)
Income tax (expense) benefit	(22,288)	344	(22,594)	(1,006)
Net loss attributable to common stockholders	$ (69,692)	$ (59,997)	$ (363,806)	$ (173,899)
Weighted-average shares outstanding:
Basic and diluted (in shares)	67,641,171	56,463,528	65,068,281	57,798,968
Net loss per share-basic and diluted (in dollars per share)
Net loss per share-basic and diluted (in dollars per share)	$ (1.03)	$ (1.06)	$ (5.59)	$ (3.01)
Net product revenue
Revenues:
Revenue	$ 82,708	$ 71,369	$ 226,143	$ 209,899
Collaboration and grant revenue
Revenues:
Revenue	35,000	47	35,063	622
Royalty revenue
Revenues:
Revenue	$ 696	$ 0	$ 696	$ 0