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Intangible assets and goodwill - Narrative (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 4 Months Ended 12 Months Ended
May 31, 2019
Dec. 31, 2018
Dec. 31, 2018
Dec. 31, 2019
Dec. 31, 2018
Dec. 31, 2017
Aug. 23, 2018
Apr. 20, 2017
Finite-Lived Intangible Assets [Line Items]                
Useful life       7 years        
Amortization of acquired intangible asset       $ 27,650 $ 22,877 $ 15,380    
Finite-Lived Intangible Assets, Remaining Amortization Period       4 years 6 months        
Goodwill   $ 82,341 $ 82,341 $ 82,341 82,341      
Goodwill adjustment   18,000            
Akcea                
Finite-Lived Intangible Assets [Line Items]                
Milestone, potential achievements, regulatory approval       $ 4,000        
Upfront licensing fee $ 6,000       12,000      
Non-collaborative Arrangement Transactions | Akcea                
Finite-Lived Intangible Assets [Line Items]                
Useful life       10 years        
Milestone, potential achievements, regulatory approval $ 6,000     $ 4,000        
Emflaza asset acquisition                
Finite-Lived Intangible Assets [Line Items]                
Intangibles assets of Emflaza               $ 148,373
Milestone, potential achievements, regulatory approval   14,400 14,400 27,100 14,400      
Marathon Pharmaceuticals, LLC                
Finite-Lived Intangible Assets [Line Items]                
Development milestone payment obligations       11,400        
Agilis                
Finite-Lived Intangible Assets [Line Items]                
Development milestone payment obligations       40,000     $ 40,000  
Goodwill   82,341 82,341 82,300 82,341   100,309  
Goodwill adjustment     (17,968)          
Agilis | Non-collaborative Arrangement Transactions                
Finite-Lived Intangible Assets [Line Items]                
Development milestone payment obligations       40,000     40,000  
Intellectual Property                
Finite-Lived Intangible Assets [Line Items]                
Accumulated amortization       $ 65,900        
In Process Research and Development [Member] | Agilis                
Finite-Lived Intangible Assets [Line Items]                
Intangible assets, other than goodwill   $ 576,500 $ 576,500   $ 576,500   $ 480,000