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The Company (Details) - USD ($)
$ in Thousands
1 Months Ended
Oct. 25, 2019
Aug. 23, 2018
Apr. 20, 2017
Aug. 31, 2014
Dec. 31, 2019
Sep. 30, 2019
Dec. 31, 2018
Aug. 31, 2015
Minimum age of ambulatory patient       5 years        
Accumulated deficit         $ (1,190,499)   $ (938,923)  
Convertible Senior Notes, 1.5%, Due September 15, 2026 | Convertible debt                
Interest rate         1.50% 1.50%    
3.00% Convertible senior notes due 2022 | Convertible debt                
Interest rate               3.00%
Marathon Pharmaceuticals, LLC | Non-collaborative Arrangement Transactions                
Cash consideration     $ 75,000          
Equity interest issued or issuable, number of shares (in shares)     6,683,598          
Numerator for calculation of number of shares of equity interests issued to acquire entity     $ 65,000          
Trading day period     15 days          
Development milestone payment obligations     $ 50,000          
Agilis                
Cash consideration   $ 49,221            
Equity interest issued or issuable, number of shares (in shares)   3,500,907            
Numerator for calculation of number of shares of equity interests issued to acquire entity   $ 150,000            
Trading day period   10 days            
Development milestone payment obligations   $ 40,000     $ 40,000      
Agilis | Non-collaborative Arrangement Transactions                
Development milestone payment obligations   $ 40,000     40,000      
Maximum | Agilis                
Development milestone payment obligations         60,000      
Net sales milestones         150,000      
Maximum | BioElectron                
Development milestone payment obligations         200,000      
BioElectron                
Cash consideration $ 10,000              
Development milestone payment obligations         $ 200,000      
Loan advance 4,000              
Escrow deposit disbursements related to property acquisition 1,500              
BioElectron | Maximum                
Net sales milestones $ 200,000