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Selected quarterly financial data (Unaudited)
12 Months Ended
Dec. 31, 2019
Quarterly Financial Information Disclosure [Abstract]  
Selected quarterly financial data (Unaudited) Selected quarterly financial data (Unaudited)
The following financial information reflects all normal recurring adjustments, which are, in the opinion of management, necessary for a fair statement of the results of the interim periods. Summarized quarterly data for 2019 and 2018 are as follows:
 
 
For the quarters ending (1)
 
 
March 31
 
June 30
 
September 30
 
December 31
2019:
 
 

 
 

 
 

 
 

Net product revenue
 
$
53,054

 
$
85,476

 
$
71,369

 
$
81,407

Collaboration and grant revenue
 
529

 
46

 
47

 
15,052

Operating expenses
 
122,723

 
124,280

 
131,891

 
169,243

Loss income from operations
 
(69,140
)
 
(38,758
)
 
(60,475
)
 
(72,784
)
Net loss
 
(72,113
)
 
(41,789
)
 
(59,997
)
 
(77,677
)
Basic and diluted net loss per common share(1)
 
$
(1.29
)
 
$
(0.75
)
 
$
(1.06
)
 
$
(1.37
)
2018:
 
 

 
 

 
 

 
 

Net product revenue
 
$
55,981

 
$
68,170

 
$
53,021

 
$
85,833

Collaboration and grant revenue
 
81

 
573

 
570

 
505

Operating expenses
 
72,805

 
74,317

 
101,821

 
131,476

Loss from operations
 
(16,743
)
 
(5,574
)
 
(48,230
)
 
(45,138
)
Net loss
 
(19,263
)
 
(9,520
)
 
(50,969
)
 
(48,330
)
Basic and diluted net loss per common share(1)
 
$
(0.46
)
 
$
(0.21
)
 
$
(1.06
)
 
$
0.96

 
(1)
The amounts were computed independently for each quarter and the sum of the quarters may not total the annual amounts.