XML 98 R85.htm IDEA: XBRL DOCUMENT v3.10.0.1
Income taxes - Narrative (Details) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Operating loss carryforwards      
Valuation allowance $ 180,481 $ 177,631  
Valuation allowance, deferred tax asset, increase (decrease) 2,800 $ 5,400  
Deferred Tax Assets, Operating Loss Carryforwards, Limited by IRC Section 382 231,500    
Orphan drug credit carryover 74,000    
Limited NOL carryforwards 231,500    
Operating loss carryforwards, not subject to expiration 169,200    
Operating loss carryforwards, subject to expiration 62,300    
Operating loss carryforwards for immediate use 194,500    
Operating loss carryforwards in next twelve months $ 5,700    
Federal income tax provision at statutory rate 21.00% 34.00% 34.00%
Uncertain tax position $ 0    
Change In tax rate, deferred tax asset, provisional income tax expense 46,100    
First five years from ownership change      
Operating loss carryforwards      
Net operating loss carryforwards 16,700    
After five years      
Operating loss carryforwards      
Net operating loss carryforwards 5,700    
Federal      
Operating loss carryforwards      
Net operating loss carryforwards 296,000    
Research and development credit carryforwards 15,200    
State      
Operating loss carryforwards      
Net operating loss carryforwards 202,400    
Research and development credit carryforwards 6,600    
Foreign Tax Authority      
Operating loss carryforwards      
Net operating loss carryforwards $ 5,900