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Earnings per share (Details) - USD ($)
$ / shares in Units, $ in Thousands
3 Months Ended 12 Months Ended
Dec. 31, 2018
Sep. 30, 2018
Jun. 30, 2018
Mar. 31, 2018
Dec. 31, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Net loss per share:                      
Basic and diluted (in dollars per share) $ (0.96) $ (1.06) $ (0.21) $ (0.46) $ 0.03 $ (0.82) $ (0.44) $ (0.85) $ (2.75) $ (2.02) $ (4.17)
Numerator                      
Net loss $ (48,330) $ (50,969) $ (9,520) $ (19,263) $ 1,270 $ (33,738) $ (17,475) $ (29,057) $ (128,081) $ (79,000) $ (142,110)
Denominator                      
Denominator for basic and diluted net loss per share (in shares)                 46,576,313 39,183,073 34,044,584
Total shares excluded from calculation (in shares)                 9,105,837 6,841,653 6,125,967
Stock Options                      
Denominator                      
Total shares excluded from calculation (in shares)                 8,534,358 6,448,642 5,854,316
Unvested restricted stock                      
Denominator                      
Total shares excluded from calculation (in shares)                 571,479 393,011 271,651