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Collaborations and grants (Details)
1 Months Ended 12 Months Ended
Jan. 02, 2011
deliverable
Oct. 31, 2017
USD ($)
Nov. 30, 2014
USD ($)
Jan. 31, 2014
USD ($)
Nov. 30, 2011
USD ($)
compound
Dec. 31, 2017
USD ($)
deliverable
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Collaborations and grants                
Grant revenue           $ 0 $ 900,000 $ 2,200,000
Minimum                
Collaborations and grants                
Term of grant program           2 years    
Maximum                
Collaborations and grants                
Term of grant program           5 years    
Collaboration agreement | Development event milestones                
Collaborations and grants                
Collaboration revenue recognized   $ 20,000,000 $ 10,000,000 $ 7,500,000        
Collaboration agreement | Roche and SMA Foundation                
Collaborations and grants                
Number of compounds in preclinical development | compound         3      
Deferred revenue         $ 30,000,000      
Number of significant deliverables | deliverable           2    
Research period for applying technology         2 years      
Collaboration revenue recognized           $ 20,300,000 400,000 $ 600,000
Collaboration agreement | Roche and SMA Foundation | Development event milestones                
Collaborations and grants                
Additional consideration receivable upon achievement of specified events           135,000,000    
Collaboration agreement | Roche and SMA Foundation | Sales milestones                
Collaborations and grants                
Additional consideration receivable upon achievement of specified events           325,000,000    
Early stage collaboration and discovery agreements                
Collaborations and grants                
Deferred revenue           $ 0 0  
Number of significant deliverables | deliverable 2              
Collaboration revenue recognized             $ 1,800,000  
Early stage collaboration and discovery agreements | Minimum                
Collaborations and grants                
Research period for applying technology           3 years    
Early stage collaboration and discovery agreements | Maximum                
Collaborations and grants                
Research period for applying technology           4 years    
Early stage collaboration and discovery agreements | Development event milestones                
Collaborations and grants                
Additional consideration receivable upon achievement of specified events           $ 143,000,000    
Early stage collaboration and discovery agreements | Sales milestones | Maximum                
Collaborations and grants                
Additional consideration receivable upon achievement of specified events           $ 252,000,000