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Net loss per share - Antidilutive (Details) - shares
9 Months Ended
Sep. 30, 2016
Sep. 30, 2015
Net loss per share    
Total shares excluded from calculation 6,104,745 5,141,399
Stock Options    
Net loss per share    
Total shares excluded from calculation 5,832,166 4,788,264
Unvested restricted stock awards and units    
Net loss per share    
Total shares excluded from calculation 272,579 353,135