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Selected quarterly financial data (Details) (USD $)
In Thousands, except Per Share data, unless otherwise specified
1 Months Ended 3 Months Ended 12 Months Ended
Jul. 31, 2012
Dec. 31, 2014
Sep. 30, 2014
Jun. 30, 2014
Mar. 31, 2014
Dec. 31, 2013
Sep. 30, 2013
Jun. 30, 2013
Mar. 31, 2013
Dec. 31, 2014
Dec. 31, 2013
Dec. 31, 2012
Selected quarterly financial data                        
Net Product Sales   $ 636ptct_NetProductSales $ 81ptct_NetProductSales             $ 717ptct_NetProductSales    
Collaboration and grant revenue   12,022ptct_CollaborationAndGrantRevenue 1,613ptct_CollaborationAndGrantRevenue 1,677ptct_CollaborationAndGrantRevenue 9,217ptct_CollaborationAndGrantRevenue 4,411ptct_CollaborationAndGrantRevenue 16,290ptct_CollaborationAndGrantRevenue 6,854ptct_CollaborationAndGrantRevenue 7,142ptct_CollaborationAndGrantRevenue      
Operating Expenses   44,888us-gaap_OperatingExpenses 29,295us-gaap_OperatingExpenses 27,046us-gaap_OperatingExpenses 23,429us-gaap_OperatingExpenses 22,503us-gaap_OperatingExpenses 20,565us-gaap_OperatingExpenses 21,307us-gaap_OperatingExpenses 15,718us-gaap_OperatingExpenses 124,658us-gaap_OperatingExpenses 80,094us-gaap_OperatingExpenses 60,754us-gaap_OperatingExpenses
Loss from operations   (32,230)us-gaap_OperatingIncomeLoss (27,601)us-gaap_OperatingIncomeLoss (25,369)us-gaap_OperatingIncomeLoss (14,212)us-gaap_OperatingIncomeLoss (18,093)us-gaap_OperatingIncomeLoss (4,276)us-gaap_OperatingIncomeLoss (14,453)us-gaap_OperatingIncomeLoss (8,576)us-gaap_OperatingIncomeLoss (99,413)us-gaap_OperatingIncomeLoss (45,398)us-gaap_OperatingIncomeLoss (26,808)us-gaap_OperatingIncomeLoss
Net loss           (17,886)us-gaap_NetIncomeLoss (4,416)us-gaap_NetIncomeLoss (14,587)us-gaap_NetIncomeLoss (14,685)us-gaap_NetIncomeLoss (93,753)us-gaap_NetIncomeLoss (51,574)us-gaap_NetIncomeLoss (26,235)us-gaap_NetIncomeLoss
Deemed Dividend                 18,249ptct_DeemedDividend   18,249ptct_DeemedDividend  
Gain on exchange of convertible preferred stock in connection with recapitalization 160,000us-gaap_PreferredStockRedemptionDiscount               3,391us-gaap_PreferredStockRedemptionDiscount   3,391us-gaap_PreferredStockRedemptionDiscount 159,954us-gaap_PreferredStockRedemptionDiscount
Less beneficial conversion charge                       (378)us-gaap_PreferredStockConversionsInducements
Net income (loss) attributable to common stockholders   $ (27,269)us-gaap_ProfitLoss $ (27,282)us-gaap_ProfitLoss $ (25,104)us-gaap_ProfitLoss $ (14,098)us-gaap_ProfitLoss $ (17,886)us-gaap_ProfitLoss $ (4,416)us-gaap_ProfitLoss $ (14,587)us-gaap_ProfitLoss $ (29,543)us-gaap_ProfitLoss $ (93,753)us-gaap_ProfitLoss $ (66,432)us-gaap_ProfitLoss $ 133,341us-gaap_ProfitLoss
Basic net income (loss) per common share   $ (0.84)us-gaap_EarningsPerShareBasic $ (0.93)us-gaap_EarningsPerShareBasic $ (0.86)us-gaap_EarningsPerShareBasic $ (0.58)us-gaap_EarningsPerShareBasic $ (0.75)us-gaap_EarningsPerShareBasic $ (0.19)us-gaap_EarningsPerShareBasic $ (5.51)us-gaap_EarningsPerShareBasic $ (6,527.30)us-gaap_EarningsPerShareBasic $ (2.97)us-gaap_EarningsPerShareBasic $ (5.18)us-gaap_EarningsPerShareBasic $ 219.76us-gaap_EarningsPerShareBasic
Diluted net income (loss) per common share   $ (0.84)us-gaap_EarningsPerShareDiluted $ (0.93)us-gaap_EarningsPerShareDiluted $ (0.86)us-gaap_EarningsPerShareDiluted $ (0.58)us-gaap_EarningsPerShareDiluted $ (0.75)us-gaap_EarningsPerShareDiluted $ (0.19)us-gaap_EarningsPerShareDiluted $ (5.51)us-gaap_EarningsPerShareDiluted $ (6,527.30)us-gaap_EarningsPerShareDiluted $ (2.97)us-gaap_EarningsPerShareDiluted $ (5.18)us-gaap_EarningsPerShareDiluted $ 42.50us-gaap_EarningsPerShareDiluted