21^st Century Holding Company

EXHIBIT 32.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT

In connection with the Quarterly Report on Form 10-Q of 21^st Century Holding Company for the quarter ended March 31, 2007 as filed with the Securities and Exchange Commission (the “Report”), I, Edward J. Lawson, Chief Executive Officer of 21^st Century Holding Company, hereby certify pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of 21^st Century Holding Company.

By:  /s/ Edward J. Lawson
Edward J. Lawson, Chief Executive Officer	May 10, 2007