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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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<SEC-DOCUMENT>0001069308-09-000002.txt : 20090427
<SEC-HEADER>0001069308-09-000002.hdr.sgml : 20090427
<ACCEPTANCE-DATETIME>20090427121653
ACCESSION NUMBER:		0001069308-09-000002
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		Rule 506
FILED AS OF DATE:		20090427
DATE AS OF CHANGE:		20090427
EFFECTIVENESS DATE:		20090427

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Opexa Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001069308
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				760333165
		STATE OF INCORPORATION:			TX
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-70270
		FILM NUMBER:		09771757

	BUSINESS ADDRESS:	
		STREET 1:		2635 N. CRESCENT RIDGE DRIVE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381
		BUSINESS PHONE:		(281) 272-9331

	MAIL ADDRESS:	
		STREET 1:		2635 N. CRESCENT RIDGE DRIVE
		CITY:			THE WOODLANDS
		STATE:			TX
		ZIP:			77381

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PharmaFrontiers Corp.
		DATE OF NAME CHANGE:	20051011

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	PHARMAFRONTIERS CORP
		DATE OF NAME CHANGE:	20040816

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	SPORTAN UNITED INDUSTRIES INC
		DATE OF NAME CHANGE:	19990305
</SEC-HEADER>
<DOCUMENT>
<TYPE>D
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<edgarSubmission>

    <schemaVersion>X0301</schemaVersion>

    <submissionType>D</submissionType>

    <testOrLive>LIVE</testOrLive>

    <primaryIssuer>
        <cik>0001069308</cik>
        <entityName>Opexa Therapeutics, Inc.</entityName>
        <issuerAddress>
            <street1>2635 N. CRESCENT RIDGE DRIVE</street1>
            <street2></street2>
            <city>THE WOODLANDS</city>
            <stateOrCountry>TX</stateOrCountry>
            <zipCode>77381</zipCode>
        </issuerAddress>
        <issuerPhoneNumber>(281) 272-9331</issuerPhoneNumber>
        <issuerPreviousNameList>
            <previousName>PharmaFrontiers Corp.</previousName>
            <previousName>PHARMAFRONTIERS CORP</previousName>
            <previousName>SPORTAN UNITED INDUSTRIES INC</previousName>
        </issuerPreviousNameList>
        <jurisdictionOfInc>TX</jurisdictionOfInc>
        <entityType>Corporation</entityType>
        <yearOfInc>
            <overFiveYears>true</overFiveYears>
        </yearOfInc>
    </primaryIssuer>

    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Neil</firstName>
                <middleName>K.</middleName>
                <lastName>Warma</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2635 N. Crescent Ridge Drive</street1>
                <street2></street2>
                <city>The Woodlands</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>77381</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName></middleName>
                <lastName>Hung</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2635 N. Crescent Ridge Drive</street1>
                <street2></street2>
                <city>The Woodlands</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>77381</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>B.</middleName>
                <lastName>McWilliams</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2635 N. Crescent Ridge Drive</street1>
                <street2></street2>
                <city>The Woodlands</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>77381</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>E.</middleName>
                <lastName>Jorden</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2635 N. Crescent Ridge Drive</street1>
                <street2></street2>
                <city>The Woodlands</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>77381</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Michael</firstName>
                <middleName>S.</middleName>
                <lastName>Richman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2635 N. Crescent Ridge Drive</street1>
                <street2></street2>
                <city>The Woodlands</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>77381</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Scott</firstName>
                <middleName>B.</middleName>
                <lastName>Seaman</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2635 N. Crescent Ridge Drive</street1>
                <street2></street2>
                <city>The Woodlands</city>
                <stateOrCountry>TX</stateOrCountry>
                <zipCode>77381</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
    </relatedPersonsList>

    <offeringData>
        <industryGroup>
            <industryGroupType>Biotechnology</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>No Revenues</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2009-04-14</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isOtherType>true</isOtherType>
            <descriptionOfOtherType>Offering was for Issuer's Units. Each Unit consists of (A) $10,000 convertible note, convertible into 15,000 shs of Issuer's common stock at $0.75 p/share &amp; (B) Series G Warrant to purchase 10,000 shs of Issuer's common stock at $0.50 p/share.</descriptionOfOtherType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>false</isBusinessCombinationTransaction>
            <clarificationOfResponse></clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>1000</minimumInvestmentAccepted>
        <salesCompensationList>
            <recipient>
                <recipientName>Cambria Capital, LLC</recipientName>
                <recipientCRDNumber>133760</recipientCRDNumber>
                <associatedBDName>None</associatedBDName>
                <associatedBDCRDNumber>None</associatedBDCRDNumber>
                <recipientAddress>
                    <street1>66 Exchange Place</street1>
                    <street2>Suite 200</street2>
                    <city>Salt Lake City</city>
                    <stateOrCountry>UT</stateOrCountry>
                    <zipCode>84111</zipCode>
                </recipientAddress>
                <statesOfSolicitationList>
                    <state>CA</state>
                    <state>CT</state>
                    <state>NY</state>
                    <state>OK</state>
                    <state>UT</state>
                </statesOfSolicitationList>
            </recipient>
        </salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>2000000</totalOfferingAmount>
            <totalAmountSold>1101000</totalAmountSold>
            <totalRemaining>899000</totalRemaining>
            <clarificationOfResponse>For the purposes of this Form D, a market value of $10,000 per Unit of the Company (&quot;Unit&quot;) was assigned to each Unit sold to offerees pursuant to this private offering.</clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>28</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>41600</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse>As additional consideration, Cambria Capital, LLC received a Series G Warrant to purchase 87,360 shares of Common Stock of Opexa Therapeutics, Inc. at an exercise price of $0.50 per share.</clarificationOfResponse>
        </salesCommissionsFindersFees>
        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Opexa Therapeutics, Inc.</issuerName>
                <signatureName>/s/ Neil K. Warma</signatureName>
                <nameOfSigner>Neil K. Warma</nameOfSigner>
                <signatureTitle>President &amp; CEO</signatureTitle>
                <signatureDate>2009-04-27</signatureDate>
            </signature>
        </signatureBlock>
    </offeringData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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