PGIM INVESTMENTS LLC

655 Broad Street

Newark, New Jersey 07102

July 3, 2019

VIA EDGAR

U.S. Securities and Exchange Commission

100 F Street, NE

Washington, D.C. 20549

Re: 497 Filing for

Prudential Investment Portfolios, Inc. 16 (Registration numbers 333-60561 and 811-08915) PGIM Income Builder Fund (the “Fund”)

Dear Sir or Madam:

We are filing today via EDGAR an exhibit under Rule 497 containing interactive data format risk/return summary information. The exhibit mirrors the risk/return summary information in a Prospectus dated July 1, 2019 (SEC accession number 0001683863-19-001611) for the Fund listed above. The purpose of the filing is to submit the 497 filing dated July 1, 2019 in XBRL.

Thank you for your attention to this filing. Please direct any questions regarding this filing to the undersigned at (973) 367-8982.

Sincerely,

/s/ Diana Huffman

Diana Huffman

Assistant Secretary