UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 14A

Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934 (Amendment No.     )

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Filed by a Party other than the Registrant  o
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o	Definitive Proxy Statement
x	Definitive Additional Materials
o	Soliciting Material under §240.14a-12
Prudential Investment Portfolios 16
(Name of Registrant as Specified In Its Charter)
(Name of Person(s) Filing Proxy Statement, if other than the Registrant)
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Shareholder Name

Address 1

Address 2

Address 3

October 26, 2018

IMPORTANT DEADLINE

Subject: PGIM QMA DEFENSIVE EQUITY FUND,

a series of Prudential Investment Portfolios 16

Dear Shareholder:

We have been unable to reach you to discuss important changes affecting one or more of your investments in the of PGIM QMA Defensive Equity Fund (formerly, Prudential QMA Defensive Equity Fund), a series of Prudential Investment Portfolios 16.  We are requesting your prompt response no later than November 16, 2018. A shareholder meeting to allow shareholders to vote on changes to the funds is scheduled on November 16, 2018.

Please call the number below before November 16. It will only take a few minutes of your time, and there is no confidential information required.

You can reach our proxy solicitor, AST Fund Solutions, at 1-866-828-6951 between 9 a.m. and 10 p.m. Eastern Time, Monday through Friday. When you call, please provide the reference number listed below.

Thank you in advance for your assistance.

Sincerely,

Peter Parrella

Assistant Treasurer

REFERENCE NUMBER:  123456789